癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
COCH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O43405 |
| Other Accession | Q5EA64, NP_004077.1, NP_001128530.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59483 Da |
| Antigen Region | 492-520 aa |
| Gene ID | 1690 |
|---|---|
| Other Names | Cochlin, COCH-5B2, COCH, COCH5B2 |
| Target/Specificity | This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human COCH. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COCH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COCH |
|---|---|
| Synonyms | COCH5B2 |
| Function | Plays a role in the control of cell shape and motility in the trabecular meshwork. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed in inner ear structures; the cochlea and the vestibule |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq].
REFERENCES
Ikezono, T., et al. Acta Otolaryngol. 130(8):881-887(2010)
Yao, J., et al. J. Biol. Chem. 285(20):14909-14919(2010)
Baek, J.I., et al. Clin. Genet. 77(4):399-403(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lee, E.S., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2060-2066(2010)
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