癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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GPR142 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q7Z601 |
| Other Accession | NP_861455.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51106 Da |
| Antigen Region | 86-114 aa |
| Gene ID | 350383 |
|---|---|
| Other Names | Probable G-protein coupled receptor 142, G-protein coupled receptor PGR2, GPR142, PGR2 |
| Target/Specificity | This GPR142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the N-terminal region of human GPR142. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR142 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR142 (HGNC:20088) |
|---|---|
| Function | Highly selective G protein-coupled receptor for aromatic amino acids specifically L-Tryptophan (L-Trp) and L-Phenylalanine (L- Phe), with L-Trp being the most potent and efficacious agonist (PubMed:27104960, PubMed:27322810). GPR142 agonists triggers the activation of both GNAQ/G(q) and GNAI1/G(i)-coupled signaling pathways (PubMed:27104960). L-Trp stimulates glucose-induced insulin secretion and triggers G(q)-mediated signaling (By similarity). GPR142 appears to have a role as a sensor of aromatic essential amino acids controlling the secretion of both insulin in the pancreas and other gastrointestinal hormones including glucagon but also CCK and incretin in the gastrointestinal-tract, contributing to the control of glucose homeostasis by coordinating pancreatic and gut hormone secretion (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed mainly in pancreatic islet and enteroendocrine cells (PubMed:30472415). Expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).
REFERENCES
Matsuo, A., et al. Biochem. Biophys. Res. Commun. 331(1):363-369(2005)
Fredriksson, R., et al. FEBS Lett. 554(3):381-388(2003)
Vassilatis, D.K., et al. Proc. Natl. Acad. Sci. U.S.A. 100(8):4903-4908(2003)
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¥ 1,250.00
Cat# AP11260a
