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SARS Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SARS Antibody (N-term) AP11092a
    SARS Antibody (N-term) (Cat. #AP11092a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SARS antibody detected the SARS protein (arrow).
  • 1 - SARS Antibody (N-term) AP11092a
    Western blot analysis of SARS (arrow) using rabbit polyclonal SARS Antibody (N-term) (Cat. #AP11092a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SARS gene.
  • 14 - SARS Antibody (N-term) AP11092a
    SARS Antibody (N-term) (Cat. #AP11092a)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SARS Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P49591
Other Accession NP_006504.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 58777 Da
Antigen Region 140-169 aa
Additional Information
Gene ID 6301
Other Names Serine--tRNA ligase, cytoplasmic, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase, SARS, SERS
Target/Specificity This SARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the N-terminal region of human SARS.
Dilution WB~~1:1000
IHC-P~~1:100~500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSARS Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SARS1 (HGNC:10537)
Synonyms SARS, SERS
Function Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys- 16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000).
Cellular Location Cytoplasm. Nucleus Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus.
Tissue Location Brain..
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq].

REFERENCES

Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Herzog, W., et al. Circ. Res. 104(11):1260-1266(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)

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