癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZDHHC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WTX9 |
| Other Accession | Q8R0N9, NP_037436.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54818 Da |
| Antigen Region | 14-43 aa |
| Gene ID | 29800 |
|---|---|
| Other Names | Probable palmitoyltransferase ZDHHC1, DHHC domain-containing cysteine-rich protein 1, Zinc finger DHHC domain-containing protein 1, DHHC-1, Zinc finger protein 377, ZDHHC1, C16orf1, ZNF377 |
| Target/Specificity | This ZDHHC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human ZDHHC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZDHHC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZDHHC1 {ECO:0000303|PubMed:39173637, ECO:0000312|HGNC:HGNC:17916} |
|---|---|
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3 (PubMed:39173637). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7 (PubMed:39173637). |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q8R0N9}; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus |
| Tissue Location | Widely expressed with significant expression in heart, brain, placenta, lung, liver, kidney, testis, thymus and small intestine (PubMed:16647879). Expressed at lower levels in adult pancreas and lung (PubMed:10395086). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)
Putilina, T., et al. Mol. Cell. Biochem. 195 (1-2), 219-226 (1999) :
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Cat# AP10315a
