癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GAS2L1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q99501 |
| Other Accession | Q8JZP9, NP_689422.1, NP_689423.1, NP_006469.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72717 Da |
| Antigen Region | 618-646 aa |
| Gene ID | 10634 |
|---|---|
| Other Names | GAS2-like protein 1, GAS2-related protein on chromosome 22, Growth arrest-specific protein 2-like 1, GAS2L1, GAR22 |
| Target/Specificity | This GAS2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 618-646 amino acids from the C-terminal region of human GAS2L1. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GAS2L1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GAS2L1 |
|---|---|
| Synonyms | GAR22 |
| Function | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Colocalizes with the tips of microtubule plus ends. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene.
REFERENCES
Saito, A., et al. Psychiatry Res (2010) In press :
Gamper, I., et al. Exp. Hematol. 37(5):539-548(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Goriounov, D., et al. J. Cell. Sci. 116 (PT 6), 1045-1058 (2003) :
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