癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADAMTS10 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H324 |
| Other Accession | NP_112219.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 120874 Da |
| Antigen Region | 210-240 aa |
| Gene ID | 81794 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 10, ADAM-TS 10, ADAM-TS10, ADAMTS-10, 3424-, ADAMTS10 |
| Target/Specificity | This ADAMTS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the N-terminal region of human ADAMTS10. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADAMTS10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS10 |
|---|---|
| Function | Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Widely expressed in adult tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
REFERENCES
Morales, J., et al. Am. J. Hum. Genet. 85(5):558-568(2009)
Ben Yahia, S., et al. J. Hum. Genet. 54(9):550-553(2009)
Kutz, W.E., et al. Hum. Mutat. 29(12):1425-1434(2008)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Dagoneau, N., et al. Am. J. Hum. Genet. 75(5):801-806(2004)
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