癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Draxin (C-terminal region) Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q8NBI3 |
| Host | Rabbit |
| Clonality | Rabbit Polyclonal |
| Isotype | IgG |
| Calculated MW | 38650 Da |
| Gene ID | 374946 |
|---|---|
| Other Names | C1orf187 |
| Target/Specificity | The developing nervous system assembles with the help of guidance molecules that control the trajectory of growing neurons. Axon guidance proteins such as, netrins, semaphorins, ephrins, and slits, are critical extracellular matrix cues for correctly wiring of the nervous system. Draxin is an axon guidance protein that has been observed to repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Chick draxin consists of 349 amino acids with a putative signal peptide sequence at the N-terminal end but no membrane anchoring sequence, which suggests that draxin is a secreted protein. The ectopically expressed draxin has been shown to inhibit growth or cause misrouting of chick spinal cord commissural axons in vivo. In both chick and mouse, commissural neurons require draxin to successfully cross the midline and form the major commissures of the brain. Thus, draxin is a chemorepulsive axon guidance molecule required for the development of the spinal cord and forebrain commissures. |
| Dilution | WB~~1:1000 ICC~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Draxin (C-terminal region) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The developing nervous system assembles with the help of guidance molecules that control the trajectory of growing neurons. Axon guidance proteins such as, netrins, semaphorins, ephrins, and slits, are critical extracellular matrix cues for correctly wiring of the nervous system. Draxin is an axon guidance protein that has been observed to repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Chick draxin consists of 349 amino acids with a putative signal peptide sequence at the N-terminal end but no membrane anchoring sequence, which suggests that draxin is a secreted protein. The ectopically expressed draxin has been shown to inhibit growth or cause misrouting of chick spinal cord commissural axons in vivo. In both chick and mouse, commissural neurons require draxin to successfully cross the midline and form the major commissures of the brain. Thus, draxin is a chemorepulsive axon guidance molecule required for the development of the spinal cord and forebrain commissures.
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