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Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody

Our Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase) primary antibody from PhosphoSolutions is r

     
  • 2 - Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody AN1342
    Immunochemical staining of saline treated mouse cortex cryosections showing specific labeling of CNP(cat. AN1342, green, 1:500). The blue is staining DNA. The bisected longitudinal mouse brain was fixed for 18h in 4% paraformaldehyde, washed, and cryoprotected in 30% sucrose overnight. The cryosections were antigen retrieved in citrate buffer, blocked in 20% normal goat serum for 1 hr. Photo courtesy of Robert Wine.
  • 1 - Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody AN1342
    Western blot of rat brain lysate showing the specific immunolabeling of the ~46 kDa CNP protein.
  • 2 - Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody AN1342
    Immunolabelling of the CA3 subfield of mouse hippocampus labeling CNP (cat. AN1342, green, 1:500) and β-III tubulin(cat. 2020-TUB, 1:1000, red). The blue is DAPI staining DNA. Original magnification is 40X. Photo courtesy Rob Wine.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P13233
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 47268 Da
Additional Information
Gene ID 25275
Other Names 2'' antibody, 2'3' cyclic nucleotide 3' phosphodiesterase antibody, 3''-cyclic-nucleotide 3''-phosphodiesterase antibody, CN37_HUMAN antibody, CNP 1 antibody, CNP antibody, CNP1 antibody, CNPase antibody
Target/Specificity 2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008).
Dilution WB~~1:1000
IHC~~1:100~500
Format Neat serum
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAnti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008).

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