GNMT Antibody (C-term)
Purified Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB, FC, E |
---|---|
Primary Accession | Q14749 |
Reactivity | Human |
Host | Mouse |
Clonality | monoclonal |
Isotype | IgG2a,k |
Clone Names | 1041CT18.2.3 |
Calculated MW | 32742 Da |
Gene ID | 27232 |
---|---|
Other Names | Glycine N-methyltransferase, 2.1.1.20, GNMT |
Target/Specificity | This GNMT antibody is generated from a mouse immunized with a recombinant protein between 1-295 amino acids from the human GNMT. |
Dilution | WB~~1:4000 FC~~1:25 E~~Use at an assay dependent concentration. |
Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GNMT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GNMT (HGNC:4415) |
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Function | Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L- homocysteine. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P13255}. |
Tissue Location | Expressed only in liver, pancreas, and prostate. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
REFERENCES
Chen Y.-M.A.,et al.Int. J. Cancer 75:787-793(1998).
Chen Y.-M.A.,et al.Genomics 66:43-47(2000).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ogawa H.,et al.Comp. Biochem. Physiol. 106B:601-611(1993).

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