癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PAX6 Antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P26367 |
| Other Accession | P63015, Q1LZF1, NP_000271.1, NP_001595.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM,K |
| Clone Names | 193CT15.2.2 |
| Calculated MW | 46683 Da |
| Gene ID | 5080 |
|---|---|
| Other Names | Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2 |
| Target/Specificity | This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6. |
| Dilution | WB~~1:500~16000 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAX6 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX6 |
|---|---|
| Synonyms | AN2 |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016} |
| Tissue Location | [Isoform 1]: Expressed in lymphoblasts. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].
REFERENCES
Gosmain, Y., et al. J. Biol. Chem. 285(43):33381-33393(2010)
Vuzman, D., et al. Biophys. J. 99(4):1202-1211(2010)
Zhang, X., et al. Cell Stem Cell 7(1):90-100(2010)
Bremond-Gignac, D., et al. Mol. Vis. 16, 1705-1711 (2010) :
Cai, F., et al. Mol. Vis. 16, 1141-1145 (2010) :
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