Anti-LYPLA2 Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IF, E
Primary Accession	O95372
Predicted	Human
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Calculated MW	24737 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	11313
Alias Symbol	LYPLA2
Other Names	LYPLA2, Acyl-protein thioesterase 2, APT-2, APT2, DJ886K2.4, LysoPLA II, LPL-II, Lysophospholipase II
Target/Specificity	Human LYPLA2
Reconstitution & Storage	Caprylic acid and ammonium sulfate precipitation
Precautions	Anti-LYPLA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	LYPLA2
Synonyms	APT2
Function	Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha- glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1- arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951).
Cellular Location	Cytoplasm.
Tissue Location	Expressed in various breast cancer cell lines.