Anti-ELOVL1 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	Q9BW60
Predicted	Human, Mouse, Rat, Monkey
Host	Rabbit
Clonality	Polyclonal
Calculated MW	32663 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	64834
Alias Symbol	ELOVL1
Other Names	ELOVL1, ELOVL FA elongase 1, ELOVL fatty acid elongase 1, Ssc1, CGI-88
Target/Specificity	Recognizes endogenous levels of ELOVL1 protein.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-ELOVL1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	ELOVL1 (HGNC:14418)
Synonyms	SSC1
Function	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs.
Cellular Location	Endoplasmic reticulum membrane {ECO:0000255\|HAMAP-Rule:MF_03201, ECO:0000269\|PubMed:20937905, ECO:0000269\|PubMed:30487246}; Multi-pass membrane protein {ECO:0000255\|HAMAP-Rule:MF_03201}
Tissue Location	Ubiquitous.