癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-UMOD / Uromodulin Antibody (clone 10.32, FITC)
Mouse Anti Human Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P07911 |
| Predicted | Human, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | 10.32 |
| Calculated MW | 69761 Da |
| Concentration (mg/ml) | 0.1 mg/ml |
| Gene ID | 7369 |
|---|---|
| Alias Symbol | UMOD |
| Other Names | UMOD, ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, Uromucoid, Tamm-Horsfall glycoprotein, HNFJ1, Uromodulin |
| Target/Specificity | Anti-human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. Tamm-Horsfall protein is a glycoprotein of approximately 80 kD containing up to 25% carbohydrate by weight. |
| Reconstitution & Storage | Protein G purified |
| Precautions | Anti-UMOD / Uromodulin Antibody (clone 10.32, FITC) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UMOD |
|---|---|
| Function | [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515). |
| Cellular Location | Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860). |
| Tissue Location | Expressed in the tubular cells of the kidney. Most abundant protein in normal urine (at protein level). Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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