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GABRP antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O00591 |
| Other Accession | NM_014211, NP_055026 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Horse |
| Predicted | Human, Mouse, Rat, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50640 Da |
| Gene ID | 2568 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit pi, GABA(A) receptor subunit pi, GABRP |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-GABRP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GABRP antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GABRP (HGNC:4089) |
|---|---|
| Function | Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548). Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (PubMed:9182563). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O09028}; Multi-pass membrane protein. Note=Located on the apical plasma membrane of alveolar epithelial type II cells {ECO:0000250|UniProtKB:O09028} |
| Tissue Location | Most abundant in non-neuronal tissues including the uterus, ovaries and also expressed in lung, thymus and prostate (PubMed:10462548, PubMed:9182563). Expressed in the hippocampus (PubMed:10462548). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
REFERENCES
Hedblom E.,et al.J. Biol. Chem. 272:15346-15350(1997).
Johnson E.K.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Sjoeblom T.,et al.Science 314:268-274(2006).
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