癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Pcsk1n Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9QXU9 |
| Other Accession | NM_019279, NP_062152 |
| Reactivity | Human, Mouse, Rat, Dog, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Dog, Guinea Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27414 Da |
| Gene ID | 246333 |
|---|---|
| Alias Symbol | Saas |
| Other Names | ProSAAS, Proprotein convertase subtilisin/kexin type 1 inhibitor, Proprotein convertase 1 inhibitor, pro-SAAS, KEP, Big SAAS, b-SAAS, Little SAAS, l-SAAS, Big PEN-LEN, b-PEN-LEN, SAAS CT(1-49), PEN, PEN-20, Little LEN, l-LEN, Big LEN, b-LEN, SAAS CT(25-40), Pcsk1n |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Pcsk1n antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Pcsk1n Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Pcsk1n |
|---|---|
| Function | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1 (PubMed:10632593, PubMed:10816562). ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q9QXV0}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9QXV0} |
| Tissue Location | Expressed in adult brain (all major structural regions), adrenal gland (medulla) and spinal cord (dorsal and ventral horn). Expressed in pancreatic islands. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Fricker L.,et al.J. Neurosci. 20:639-648(2000).
Donadel G.,et al.Neuroendocrinology 67:190-196(1998).
Qian Y.,et al.J. Biol. Chem. 275:23596-23601(2000).
Mzhavia N.,et al.Biochem. J. 361:67-76(2002).
Morgan D.J.,et al.J. Neurochem. 93:1454-1462(2005).
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