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Nfatc2 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q60591 |
| Other Accession | NM_001037178, NP_001032255 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 100020 Da |
| Gene ID | 18019 |
|---|---|
| Alias Symbol | AI607462, NFAT1, NFAT1-D, Nfatp, NF-ATc2 |
| Other Names | Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-ATp, T-cell transcription factor NFAT1, Nfatc2, Nfat1, Nfatp |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Nfatc2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Nfatc2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nfatc2 |
|---|---|
| Synonyms | Nfat1, Nfatp |
| Function | Plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (By similarity). Is involved in the negative regulation of chondrogenesis (PubMed:10620601). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription |
| Tissue Location | Expressed in spleen, heart, testis, brain, placenta, muscle and pancreas (PubMed:18675896). Expressed in the thymus (PubMed:17579027, PubMed:18675896). Expressed in the lung (PubMed:17579027). Expressed in cartilage (PubMed:10620601) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
McCaffrey P.G.,et al.Science 262:750-754(1993).
Luo C.,et al.Mol. Cell. Biol. 16:3955-3966(1996).
Plyte S.,et al.J. Biol. Chem. 276:14350-14358(2001).
Vihma H.,et al.Genomics 92:279-291(2008).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
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