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NAT8B antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9UHF3 |
| Other Accession | NM_016347, NP_057431 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Yeast |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25366 Da |
| Alias Symbol | CML2, Hcml2, MGC97061, NAT8BP |
|---|---|
| Other Names | Putative N-acetyltransferase 8B, 2.3.1.-, Acetyltransferase 1, ATase1, Camello-like protein 2, NAT8B (HGNC:30235) |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-NAT8B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NAT8B antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAT8B (HGNC:30235) |
|---|---|
| Function | Endoplasmic reticulum (ER)-membrane-bound lysine N- acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor (PubMed:19011241, PubMed:22267734, PubMed:24556617, PubMed:31945187). Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation (PubMed:19011241, PubMed:22267734). N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy (By similarity). |
| Cellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Enriched in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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