LBP antibody - C-terminal region

Rabbit Polyclonal Antibody

LBP antibody - C-terminal region (AI11907)
Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue Observed Staining: Cell membrane in endothelial cell in sinusoids
Primary Antibody
Concentration: 1:100 Other Working Concentrations: 1/600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody
Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
WB Suggested Anti-LBP Antibody Titration: 0.2-1 μg/ml
Positive Control: HepG2 cell lysate

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC
Primary Accession	P18428
Other Accession	NM_004139, NP_004130
Reactivity	Human, Pig, Horse, Bovine
Predicted	Human, Pig, Horse, Bovine
Host	Rabbit
Clonality	Polyclonal
Calculated MW	53384 Da

Additional Information
Gene ID	3929
Alias Symbol	MGC22233, BPIFD2
Other Names	Lipopolysaccharide-binding protein, LBP, LBP
Format	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage	Add 50 ul of distilled water. Final anti-LBP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
Precautions	LBP antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	LBP
Function	Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:24120359, PubMed:7517398). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24120359, PubMed:7517398).
Cellular Location	Secreted. Cytoplasmic granule membrane {ECO:0000250\|UniProtKB:P17213}. Note=Membrane- associated in polymorphonuclear Leukocytes (PMN) granules {ECO:0000250\|UniProtKB:P17213}
Tissue Location	Detected in blood serum (at protein level).