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KCNG4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8TDN1 |
| Other Accession | NM_172347, NP_758857 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58979 Da |
| Gene ID | 93107 |
|---|---|
| Alias Symbol | KV6.3, KV6.4, MGC129609, MGC4558 |
| Other Names | Potassium voltage-gated channel subfamily G member 4, Voltage-gated potassium channel subunit Kv6.4, KCNG4, KCNG3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-KCNG4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | KCNG4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNG4 (HGNC:19697) |
|---|---|
| Synonyms | KCNG3 |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the voltage-dependence of activation (PubMed:12060745, PubMed:19074135). Potassium channel subunit that does not form functional channels by itself (Probable) (PubMed:12060745). Reduces the deactivation rate (PubMed:12060745, PubMed:19074135). Modulates the threshold for activation by shifting by approximately 20 mV in hyperpolarizing direction (PubMed:12060745). Markedly changes the inactivation by shifting the voltage dependence of inactivation by approximately 40 mV in hyperpolarizing direction (PubMed:12060745). Acceleratee activation and enhances the time course of activation (PubMed:12060745). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:19074135). Colocalizes with KCNB1 at the plasma membrane (PubMed:19074135). Retains in the endoplasmic reticulum in the absence of KCNB1 (PubMed:19074135). |
| Tissue Location | Highly expressed in brain, and at lower levels in liver, small intestine and colon. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Gutman,G.A., (2005) Pharmacol. Rev. 57 (4), 473-508 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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