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Kcnd1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q03719 |
| Other Accession | NM_008423, NP_032449 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 71698 Da |
| Gene ID | 16506 |
|---|---|
| Alias Symbol | 1110037K09Rik, Kca2-1, Kv4.1, Shal, mShal1 |
| Other Names | Potassium voltage-gated channel subfamily D member 1, Voltage-gated potassium channel subunit Kv4.1, mShal, Kcnd1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Kcnd1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Kcnd1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Kcnd1 {ECO:0000312|MGI:MGI:96671} |
|---|---|
| Function | A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:28560311). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons (PubMed:28560311). Exhibits a low-threshold A- type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials (PubMed:2034678). May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior (PubMed:28560311). Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (PubMed:28560311). The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (PubMed:11423117). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9NZV8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZV8} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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