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Gabra5 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8BHJ7 |
| Other Accession | NM_176942, NP_795916 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Horse, Bovine |
| Predicted | Human, Pig, Chicken, Dog, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52274 Da |
| Gene ID | 110886 |
|---|---|
| Alias Symbol | A230018I05Rik |
| Other Names | Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5, Gabra5 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Gabra5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Gabra5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Gabra5 {ECO:0000312|MGI:MGI:95617} |
|---|---|
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing alpha-5/GABRA5 are mainly extrasynaptic and contribute to the tonic GABAergic inhibition of the hippocampus (PubMed:14993607). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (PubMed:14993607). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}. Cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644} |
| Tissue Location | Expressed in brain, in hippocampal pyramidal neurons. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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