癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Myeloid-Associated Differentiation Marker (MYADM) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone MYADM/971 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | Q96S97 |
| Other Accession | 91663, 380906 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1 |
| Clone Names | MYADM/971 |
| Calculated MW | 35274 Da |
| Gene ID | 91663 |
|---|---|
| Other Names | Myeloid-associated differentiation marker, Protein SB135, MYADM |
| Application Note | IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Myeloid-Associated Differentiation Marker (MYADM) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYADM |
|---|---|
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Not detected in thymus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Recognizes a myeloid associated differentiation antigen in the cytoplasm of mature granulocytes. It shows no reactivity with any other cell type in human tissues. Markers of myeloid cells are useful in the identification of different levels of cellular differentiation. It reacts with early precursor and mature forms of human and monkey myeloid cells. This MAb is useful for the detection of myeloid leukemias and granulocytic sarcomas. It can be used as a marker of granulocytes in normal tissues or inflammatory processes.
REFERENCES
Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Wang Q, et al. Life Sci, 2007 Jan 9. PMID 17097684 | Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid. Cui W, et al. Mol Biol Rep, 2001. PMID 12075932 | MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. Aranda JF, et al. Mol Biol Cell, 2013 Feb. PMID 23264465 | MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration. Aranda JF, et al. Mol Biol Cell, 2011 Apr 15. PMID 21325632 | Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multi-potent progenitor cells and up-regulated during myeloid differentiation. Pettersson M, et al. J Leukoc Biol, 2000 Mar. PMID 1073310
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