癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PAX7 (Rhabdomyosarcoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone PAX7/1187 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC |
|---|---|
| Primary Accession | P23759 |
| Other Accession | 5081, 113253 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | PAX7/1187 |
| Calculated MW | 55119 Da |
| Gene ID | 5081 |
|---|---|
| Other Names | Paired box protein Pax-7, HuP1, PAX7, HUP1 |
| Application Note | IHC~~1:100~500 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | PAX7 (Rhabdomyosarcoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX7 |
|---|---|
| Synonyms | HUP1 |
| Function | Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P47239}. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).
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