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Anti-Pyruvate Dehydrogenase E1-α subunit Antibody (3H2-F8-B5)
Mouse Monoclonal Antibody
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Application 
| WB, IF |
|---|---|
| Primary Accession | P08559 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 3H2-F8-B5 |
| Calculated MW | 43296 Da |
| Gene ID | 5160 |
|---|---|
| Application & Usage | WB: 293, 1299, mEsc and Tc1 cell lysates; IF: HeLa cells |
| Other Names | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I, PDHA1, PHE1A |
| Target/Specificity | Pyruvate dehydrogenase E1 component subunit alpha |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-Pyruvate Dehydrogenase E1-α subunit Antibody (3H2-F8-B5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDHA1 (HGNC:8806) |
|---|---|
| Synonyms | PHE1A |
| Function | Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex (PubMed:17474719, PubMed:19081061). The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (PubMed:19081061, PubMed:7782287). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) (Probable). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2 (PubMed:17474719, PubMed:19081061, PubMed:7782287). |
| Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:P26284} |
| Tissue Location | Ubiquitous. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle
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Discontinued
Cat# ABV12054
Size:
100 µg
Price:
¥ 3,180.00
替代产品:
