癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
G6PD Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P11413 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59257 Da |
| Antigen Region | 297-326 aa |
| Gene ID | 2539 |
|---|---|
| Other Names | Glucose-6-phosphate 1-dehydrogenase, G6PD, G6PD |
| Target/Specificity | This G6PD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-326 amino acids from the Central region of human G6PD. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | G6PD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | G6PD |
|---|---|
| Function | Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. |
| Cellular Location | Cytoplasm, cytosol. Membrane; Peripheral membrane protein |
| Tissue Location | Isoform Long is found in lymphoblasts, granulocytes and sperm |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
G6PD encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia.
REFERENCES
Louicharoen, C., et al. Science 326(5959):1546-1549(2009)
Zhong, D.N., et al. Zhongguo Dang Dai Er Ke Za Zhi 11(12):970-972(2009)
Tiono, A.B., et al. Am. J. Trop. Med. Hyg. 81(6):969-978(2009)
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马欢欢
2015-11-16 17:52:57
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Species tested
homo sapiens
Application tested
WB
Organization tested
Hela cell
Barcode encoding
0 000004 268451
Brief protocol
第一和第三道为Hela WT, 二四为G6PD KO。
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