癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Connexin 30.3 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9NTQ9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30419 Da |
| Antigen Region | 90-120 aa |
| Gene ID | 127534 |
|---|---|
| Other Names | Gap junction beta-4 protein, Connexin-303, Cx303, GJB4 |
| Target/Specificity | This Connexin 30.3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-120 amino acids from the N-terminal region of human Connexin 30.3. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Connexin 30.3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GJB4 |
|---|---|
| Function | Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q02738}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02738}. Cell junction, gap junction {ECO:0000250|UniProtKB:Q02738}. Note=Colocalizes with GJB2 at gap junction plaques in the cochlea {ECO:0000250|UniProtKB:Q02738} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.
REFERENCES
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Richard, G., et al., J. Invest. Dermatol. 120(4):601-609 (2003).
Macari, F., et al., Am. J. Hum. Genet. 67(5):1296-1301 (2000).
Lopez-Bigas, N., et al., Hum. Mutat. 19 (4), 458 (2002).
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