癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HTATIP2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BUP3 |
| Other Accession | Q9Z2G9, NP_001091991.1, NP_001091993.1, NP_001091992.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27049 Da |
| Antigen Region | 45-74 aa |
| Gene ID | 10553 |
|---|---|
| Other Names | Oxidoreductase HTATIP2, 111-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 (HGNC:16637) |
| Target/Specificity | This HTATIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human HTATIP2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HTATIP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTATIP2 (HGNC:16637) |
|---|---|
| Function | Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672). |
| Cellular Location | Cytoplasm. |
| Tissue Location | High levels in liver, lung, skeletal muscle, pancreas and placenta (PubMed:9174052). Moderate levels in heart and kidney (PubMed:9174052). Low levels in brain (PubMed:9174052). Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas (PubMed:14695192). Levels are reduced in the heart of patients with hypertrophic cardiomyopathy and failing hearts (PubMed:31468715). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
REFERENCES
Chen, X., et al. Dig. Dis. Sci. 55(8):2219-2226(2010)
Fong, S., et al. BMC Cell Biol. 11, 23 (2010) :
Nakahara, J., et al. Expert Opin. Ther. Targets 13(12):1375-1386(2009)
Tong, X., et al. Am. J. Pathol. 174(5):1931-1939(2009)
Nakahara, J., et al. J. Clin. Invest. 119(1):169-181(2009)
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