癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC23A1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q9UHI7 |
| Other Accession | NP_005838.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64815 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 9963 |
|---|---|
| Other Names | Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, hSVCT1, Yolk sac permease-like molecule 3, SLC23A1, SVCT1, YSPL3 |
| Target/Specificity | This SLC23A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC23A1. |
| Dilution | IHC-P-Leica~~1:500 WB~~1:1000-1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC23A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC23A1 (HGNC:10974) |
|---|---|
| Function | Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
REFERENCES
Timpson, N.J., et al. Am. J. Clin. Nutr. 92(2):375-382(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Michels, A.J., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1220-C1227 (2009) :
Cahill, L.E., et al. J Nutrigenet Nutrigenomics 2(6):292-301(2009)
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