癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KIAA0999 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9Y2K2 |
| Other Accession | NP_079440.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 144851 Da |
| Antigen Region | 1233-1263 aa |
| Gene ID | 23387 |
|---|---|
| Other Names | Serine/threonine-protein kinase SIK3, Salt-inducible kinase 3, SIK-3, Serine/threonine-protein kinase QSK, SIK3, KIAA0999, QSK |
| Target/Specificity | This KIAA0999 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1233-1263 amino acids from the C-terminal region of human KIAA0999. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KIAA0999 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIK3 (HGNC:29165) |
|---|---|
| Function | Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity). |
| Cellular Location | Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. |
| Tissue Location | Expressed in chondrocytes. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The specific function of the protein remains unknown.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Huang, C.J., et al. J. Cell. Mol. Med. 12 (5B), 1936-1943 (2008) :
Hashimoto, Y.K., et al. J. Cell. Biochem. 104(5):1724-1739(2008)
Kooner, J.S., et al. Nat. Genet. 40(2):149-151(2008)
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